K-7174 dihydrochloride estin (ML246) A pan-NADPH Oxidase Inhibitor Ameliorates

A pan-NADPH Oxidase Inhibitor Ameliorates Kidney Injury in Type 1 Diabetic Rats

Gramine inhibits angiogenesis and induces apoptosis via modulation of TGF-β signalling in 7

Appearance: Solid powder

Formula: C30H30Cl2N4O4

1186/1476-4598-8-62

K-7174 dihydrochloride estin (ML246) A pan-NADPH Oxidase Inhibitor AmelioratesK 7174 is a novel orally active, potent proteasome inhibitor. K 7174 exerts anti myeloma activity in vitro and in vivo by down regulating the expression of class I histone deacetylases. K 7174 kills bortezomib resistant myeloma cells carrying a 5 subunit mutation in vivo and primary cells from a patient resistant to bortezomib. K 7174 is also a GATA specific inhibitor, which may have potential application in treating anemia of chronic disease. Product