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Current evidence comes mostly from trials funded by the drug makers, with multiple sources of bias

Firstly, excess adipose tissue increases aromatase activity, leading to enhanced conversion of testosterone to oestradiol

The appetite suppression that semaglutide provides works through multiple pathways

References: Montecinos, K

Hemoglobin A1c levels typically rise within weeks to months after discontinuing GLP-1 therapy, returning toward pre-treatment values

Non-diabetic individuals with obesity experienced an average weight reduction of 11.85% from their baseline when using semaglutide, compared to those on a placebo