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Journal of Biological Chemistry 273.32 (1998): 20378-20382

For individuals already taking antidiabetic medications including metformin, insulin, sulphonylureas, or GLP-1 receptor agonists adding berberine without medical supervision could increase the risk of hypoglycaemia (abnormally low blood sugar)

The effects of selenium supplementation might be mediated via repletion of antioxidant or immune-modulating selenoproteins, and polymorphisms in genes that encode selenoproteins might determine susceptibility to supplementation