GDC-0068 - Akt Inhibitor. CAS# 1001264-89-6 0290 It inhibits DNA methylation in

It inhibits DNA methylation in human cancer cell lines in vitro without detectable toxicity

21)27-14-6-4-13(5-7-14)25-16-9-15(23-10-24-16)11-2-1-3-12(8-11)17(22)26/h1-10H

955365-80-7

We monitored the effect of GNF-2 with AKIs on the proliferation and clonigenicity of the different Ba/F3 cells

increases β-cell mass and insulin content

GDC-0068 - Akt Inhibitor. CAS# 1001264-89-6 0290 It inhibits DNA methylation inGDC 0068, CAS No. 1001264 89 6, is a highly potent, selective, and orally available pan Akt inhibitor, targeting Akt1, Akt2 and Akt3 with IC50 of 5 nM, 18 nM and 8 nM, respectively. It has >100 fold selectivity over a broad panel of 230 kinases, except PRKG1 and PRKG1 with IC50 of 98 nM and 69 nM. GDC 0068 can effectively block Akt signaling and induce cell cycle arrest in human cancer cell lines in vitro, and exhibit significant efficacy in PTEN and