Rat Nephrin, NPHN ELISA Kit, 96T Yeast Expression Component of RNA polymerase I

Component of RNA polymerase I which synthesizes ribosomal RNA precursors

cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly

It also plays a role in nuclear pre-mRNA retention and transcriptional repression

and a short C-terminal extracellular region

Allelic variants of this gene are associated with generalized epilepsy with febrile seizures and epileptic encephalopathy

Rat Nephrin, NPHN ELISA Kit, 96T Yeast Expression Component of RNA polymerase ISeems to play a role in the development or function of the kidney glomerular filtration barrier. Regulates glomerular vascular permeability. May anchor the podocyte slit diaphragm to the actin cytoskeleton. Plays a role in skeletal muscle formation through regulation of myoblast fusion.