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If youre trying to lose weight, exercise compliments GLP-1s by helping us burn calories, reduce fat mass and preserve lean muscle mass, which helps us burn more calories

Both GLP-1 RAs (65) and SGLT2i (66) reduce visceral fat and the decrease is disproportionate to the decrease in total body fat

It also inhibits gut motility and secretion and regulates food intake

Ellenbroek et al (32) reported pancreatic weight was increased after 6 weeks on liraglutide with a 65% increase in proliferating acinar cells and no change in duct cell proliferation

For adults requiring aid in chronic weight management, we also consider Wegovy (semaglutide GLP-1), a higher dose of Semaglutide GLP-1

Additionally, tirzepatide demonstrates bias at the GLP1R, favoring the synthesis of cAMP over the recruitment of -arrestin [1]