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In December 2025, Eli Lilly released Phase 3 results from the TRIUMPH-4 trial that were even more striking: 28.7% average body weight loss (approximately 71 pounds) over 68 weeks

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Furthermore, several in vitro and in vivo evaluations demonstrated that NLC encapsulation significantly extended the plasma half-life of curcumin, maintaining therapeutic concentrations for a longer duration compared to the rapid elimination of free curcumin [109, 110]