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10.1016/j.fct.2016.07.032 127 MercantepeF.MercantepeT.TopcuA.YlmazA.TumkayaL

TZD may get his HbA1c into the desired range but is associated with adverse effects such as heart failure, edema, and weight gain

To maintain long-term metabolic benefits, most patients continue treatment indefinitely or cycle on and off under medical supervision

GLP-1 receptor agonists also suppress glucagon secretion from pancreatic alpha cells, slow gastric emptying, and promote satiety through central nervous system pathways