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[2] This would be consistent with the odd clinical picture reported a compound that increased daytime alertness and performance in the same studies where it was said to improve night sleep [7] looks more like a modulator of state regulation than a sedative

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PMID 25530442

Because of the cardiorenal benefits of RAASis, if these medications must be temporarily reduced or withheld due to hyperkalemia, a retrial of RAASi should be considered, potentially at a lower dose once hyperkalemia is resolved

Key Takeaway: Liposomal delivery uses a protective fatty shell to bypass stomach acid, increasing absorption at the cellular level while reducing the risk of digestive irritation

This suggests that GLP-1 was actively helping to tone down the brain's default activity related to appetite or self-focus, contributing to the patients' reduced desire to eat