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Phase 2 Clinical Trial Data The landmark Phase 2 trial of retatrutide in obesity was a 48-week, randomized, double-blind, placebo-controlled study published in The New England Journal of Medicine in 2023

Pharmaceutics 16(9):1139

If nausea, diarrhea, or vomiting are severe or persistent, your healthcare provider may recommend a dose adjustment or another strategy

Ultimately, this process culminates in the collapse of the glomerular plexus, giving rise to the formation of globally sclerotic glomeruli (GSG) (Martin and Sheaff, 2007)