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In a phase 2 trial of people who were overweight or had obesity, Boehringer Ingelheims survodutide, which uses both GLP-1 and glucagon, led to weight loss of 19% at 46 weeks

In addition, the frequency of your injections (usually weekly) and the overall length of your treatment plan will influence your total investment in your weight loss journey

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If you've lost less than 5%, options include: Titrating to a higher Zepbound dose Adding a second medication (e.g., metformin, topiramate) Switching to a different GLP-1 or GLP-1/GIP medication Reassessing diet, exercise, and behavioral factors Most patients who switch from Wegovy to Zepbound and titrate to at least 7.5 mg reach the 5% threshold by week 16