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Given what is known about the storage of lipophilic POPs in adipose fat, and the effect of toxin redistribution from rapid fat loss, this article is intended to draw attention to the potential for a GLP-1 Agonist POP Toxin Redistribution Axis

Swan AA, Clutton JE, Chary PK, Cook SG, Liu GG, Drew MR

Sex differences in associations of plasma metabolites with blood pressure and heart rate variability: the HELIUS study

In summary, these data provide evidence that long-term IGF-1R blockade with mAbs is feasible, well tolerated, and can recapitulate effects observed with genetic disruption of IGF-1R signaling on lifespan

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A smaller proportion achieved 5% or greater weight loss within 1 year, 71.1% (95% CI, 69.9%-72.3%) with tirzepatide and 56.4% (95% CI, 55%-57.8%) with semaglutide, resulting in an HR of 1.63 (95% CI, 1.56-1.70)