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The key principle is that any combination therapy should be initiated and monitored under close medical supervision, with dose adjustments made based on glucose monitoring results and individual patient response

PubMed Hsieh, M.J., Liu, H.T., Wang, C.N., Huang, H.Y., Lin, Y., Ko, Y.S., Wang, J.S., Chang, V.H., & Pang, J.H

Moreover, a direct interaction between SIRT2 and GCLC was further confirmed by an in vitro glutathione S-transferase (GST) pull-down assay (Fig