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It is also important to note that early-phase trials such as those conducted for retatrutide typically exclude participants with active major depressive disorder or suicidal ideation, which may limit the detection of psychiatric adverse events in the published data

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A prime example of this is tirzepatide , marketed as Mounjaro

The collection of information regarding the anti-cancer effects of drugs commonly used for other diseases could be of help in identifying potential repositionable compounds

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The three primary efficacy endpoints were assessed in this interim analysis when 50% of patients reached week 26 (end of weight-loss phase), and included percent change from baseline at week 26 in lean mass, fat mass and body weight