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Mechanisms of Action and Therapeutic Rationale Physiological Basis of GLP-1 Action GLP-1, an incretin hormone, plays a crucial role in glucose metabolism and appetite regulation, influencing insulin secretion, insulin-sensitivity, and gastric emptying [15] [16]

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We anticipate that by lowering GLP1R agonist dosing during phases associated with the highest estrogen level, the most severe side-effects could be mitigated

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