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There is no objective measurement of GLP-1 levels or body composition changes

Exenatide-induced reduction in energy intake is associated with increase in hypothalamic connectivity

It is essential, however, to be aware of potential gastrointestinal side effects associated with these treatments, including nausea and vomiting, which underscores the importance of proper dietary management

65,66 A network meta-analysis ranked SEMA 0.4 mg first in the resolution of MASH among alternative treatments [surface under the cumulative ranking (SUCRA) = 0.89], higher than liraglutide (SUCRA = 0.84) and resmetirom (SUCRA = 0.44)